Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

Keyphrases

• Leukemia 100%
• Stem Cells 100%
• Young Patients 100%
• Resistant Populations 100%
• Single-cell Omics 100%
• Hematopoietic Stem Cells 66%
• Acute Lymphoblastic Leukemia 66%
• Infant Acute Lymphoblastic Leukemia 66%
• Young Age 33%
• Chemotherapy 33%
• Cytotoxic Lymphocytes 33%
• Malignancy 33%
• Acute Myeloid Leukemia 33%
• Molecular Targets 33%
• Age at Diagnosis 33%
• Poor Outcome 33%
• Patient Outcomes 33%
• Response Pathways 33%
• Leukemic Blast 33%
• B-cell Acute Lymphoblastic Leukemia (B-ALL) 33%
• Hematopoietic Cells 33%
• Extrinsic Factors 33%
• Leukemia Cells 33%
• Initial Diagnosis 33%
• Relapse Risk 33%
• Critical Drivers 33%
• Tumor Factor 33%
• Single-cell Analysis 33%
• Lineage Plasticity 33%
• Immunotherapy Approaches 33%
• Immune-mediated 33%
• Signaling Circuits 33%
• Evade 33%

Immunology and Microbiology

• Myeloid 100%
• Lineages 100%
• Immunosuppressive Drug 50%
• Immunotherapy 50%
• Hematopoietic Cell 50%
• Cytotoxic Lymphocyte 50%
• Leukemia Cell 50%
• Steroid 50%