Abstract
Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.
Original language | English (US) |
---|---|
Pages (from-to) | 183-187 |
Number of pages | 5 |
Journal | Pharmacology |
Volume | 36 |
Issue number | 3 |
DOIs | |
State | Published - 1988 |
All Science Journal Classification (ASJC) codes
- Pharmacology