Single-dose kinetics of nifedipine in rat plasma and brain

P. K. Janicki, D. Siembab, E. A. Paulo, P. Krzaścik

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
Issue number3
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Pharmacology


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