Single-dose kinetics of nifedipine in rat plasma and brain

P. K. Janicki; D. Siembab; E. A. Paulo; P. Krzaścik

doi:10.1159/000138382

Single-dose kinetics of nifedipine in rat plasma and brain

P. K. Janicki, D. Siembab, E. A. Paulo, P. Krzaścik

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Abstract

Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C₁₈ column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	Pharmacology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1159/000138382
State	Published - 1988

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1159/000138382

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title = "Single-dose kinetics of nifedipine in rat plasma and brain",

abstract = "Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.",

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doi = "10.1159/000138382",

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AU - Janicki, P. K.

AU - Siembab, D.

AU - Paulo, E. A.

AU - Krzaścik, P.

PY - 1988

Y1 - 1988

N2 - Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

AB - Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

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Single-dose kinetics of nifedipine in rat plasma and brain

Abstract

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