Single-particle cryo-EM data acquisition by using direct electron detection camera

Shenping Wu, Jean Paul Armache, Yifan Cheng

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Recent advances in single-particle electron cryo-microscopy (cryo-EM) were largely facilitated by the application of direct electron detection cameras. These cameras feature not only a significant improvement in detective quantum efficiency but also a high frame rate that enables images to be acquired as 'movies' made of stacks of many frames. In this review, we discuss how the applications of direct electron detection cameras in cryo-EM have changed the way the data are acquired.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalMicroscopy (Oxford, England)
Issue number1
StatePublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • General Medicine


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