Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities

Jiangang Zhu, Şahin Kaya Özdemir, Lina He, Da Ren Chen, Lan Yang

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Detecting and characterizing single nanoparticles and airborne viruses are of paramount importance for disease control and diagnosis, for environmental monitoring, and for understanding size dependent properties of nanoparticles for developing innovative products. Although single particle and virus detection have been demonstrated in various platforms, single-shot size measurement of each detected particle has remained a significant challenge. Here, we present a nanoparticle size spectrometry scheme for label-free, real-time and continuous detection and sizing of single Influenza A virions, polystyrene and gold nanoparticles using split whispering-gallery-modes (WGMs) in an ultra-high-Q resonator. We show that the size of each particle and virion can be measured as they continuously bind to the resonator one-by-one, eliminating the need for ensemble measurements, stochastic analysis or imaging techniques employed in previous works. Moreover, we show that our scheme has the ability to identify the components of particle mixtures.

Original languageEnglish (US)
Pages (from-to)16195-16206
Number of pages12
JournalOptics Express
Issue number17
StatePublished - Aug 15 2011

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


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