Sleep-associated changes in interleukin-1β mRNA in the brain

Ping Taishi, Zutang Chen, Ferenc Obál, Michael K. Hansen, Jianyi Zhang, Jidong Fang, James M. Krueger

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Much evidence implicates interleukin-1β (IL-1β) in sleep regulation. Two previous studies indicated that levels of IL-1β in mRNA were affected by sleep. In the current study, levels of IL-1β mRNA and IL-1 receptor assessory protein (IL-1RAP) mRNA were determined 1 h after the beginning of light and dark periods and after sleep deprivation, using the reverse transcriptase-polymerase chain reaction (RT-PCR) and mutated internal standards. Daytime samples contained relatively more IL-1β mRNA than nighttime samples, and levels of IL-1β mRNA were higher after sleep deprivation. These changes occurred in the hypothalamus, hippocampus, cerebral cortex, and mesencephalon/pons. In contrast, the IL-1 RAP mRNA level did not seem to be affected by sleep.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of Interferon and Cytokine Research
Issue number9
StatePublished - Sep 1998

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology


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