TY - JOUR
T1 - Sleep duration and biomarkers of inflammation in African American and white participants with a parental history of Alzheimer's disease
AU - Pak, Victoria M.
AU - Paul, Sudeshna
AU - Swieboda, Dominika
AU - Balthazar, Monique S.
AU - Wharton, Whitney
N1 - Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2022
Y1 - 2022
N2 - Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race. Methods: Seventy-six cognitively normal, middle aged (45–65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed. Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), P =.000004). We found a statistically significant association between plasma IL-10 and sleep duration (Spearman's ρ = 0.26, P =.04) and CSF ICAM-1 and sleep quality (Spearman's ρ = 0.30, P =.03). Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.
AB - Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race. Methods: Seventy-six cognitively normal, middle aged (45–65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed. Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), P =.000004). We found a statistically significant association between plasma IL-10 and sleep duration (Spearman's ρ = 0.26, P =.04) and CSF ICAM-1 and sleep quality (Spearman's ρ = 0.30, P =.03). Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.
UR - http://www.scopus.com/inward/record.url?scp=85145031978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85145031978&partnerID=8YFLogxK
U2 - 10.1002/trc2.12332
DO - 10.1002/trc2.12332
M3 - Article
C2 - 36177446
AN - SCOPUS:85145031978
SN - 2352-8737
VL - 8
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
M1 - e12332
ER -
