TY - JOUR
T1 - Slow release kinetics of mitoxantrone from ordered mesoporous carbon films
AU - Labiano, Alpha
AU - Dai, Mingzhi
AU - Taylor, David
AU - Young, Wen Shiue
AU - Epps, Thomas H.
AU - Rege, Kaushal
AU - Vogt, Bryan D.
N1 - Funding Information:
AL, MD, and BDV acknowledge financial support by the National Science Foundation under Grant No. CBET-0746664. The authors thank B. O’Brien for assistance with the AFM measurements. WY and THE acknowledge AFOSR-PECASE (FA9550-09-1-0706), and ACS PRF Grant (PRF-46864-67) for financial support. KR acknowledges financial support from the National Cancer Institute, National Institutes of Health (5R21CA131891-02), and DT is a recipient of the Achievement Rewards for College Scientists (ARCS) Foundation fellowship.
PY - 2012/9/15
Y1 - 2012/9/15
N2 - High porosity and surface areas of ordered mesoporous materials provide substantial capacity for loading of guest molecules, and the well-defined morphology of such materials can control their transport for controlled release. Here, the loading and release of mitoxantrone from unmodified ordered mesoporous carbon films is monitored using UV/Vis spectroscopy. Organic-organic self-assembly of Pluronic F127 with phenolic resin leads to interconnected elliptical pores (≈2 nm) in the film after carbonization. Interestingly, the total loading (2.6 ± 0.4 μg/cm2) and release of mitoxantrone is independent of film thickness (50-400 nm), suggesting diffusion limitations in pore filling. With an alternative template, the pore size increases to ≈5 nm and the mitoxantrone loading increases to 3.5 ± 0.9 μg/cm2, but the loading still remains thickness independent. Using phosphate buffered saline at 37 °C, less than 60% of the loaded mitoxantrone is readily released from the mesoporous carbon films over a two-week period. The release profile includes an initial burst with a modest fraction (<20%) of the loaded drug released within the first day, followed by a near linear release over the subsequent 5-9 days. Interestingly, the smaller pores (ca. 2 nm) release nearly 50% more mitoxantrone over 2 weeks than the larger pores (ca. 5 nm), despite the lower initial loading. These results illustrate potential limitations as well as opportunities for the use of highly hydrophobic porous materials for the controlled release of hydrophobic biologically active compounds as drug delivery systems.
AB - High porosity and surface areas of ordered mesoporous materials provide substantial capacity for loading of guest molecules, and the well-defined morphology of such materials can control their transport for controlled release. Here, the loading and release of mitoxantrone from unmodified ordered mesoporous carbon films is monitored using UV/Vis spectroscopy. Organic-organic self-assembly of Pluronic F127 with phenolic resin leads to interconnected elliptical pores (≈2 nm) in the film after carbonization. Interestingly, the total loading (2.6 ± 0.4 μg/cm2) and release of mitoxantrone is independent of film thickness (50-400 nm), suggesting diffusion limitations in pore filling. With an alternative template, the pore size increases to ≈5 nm and the mitoxantrone loading increases to 3.5 ± 0.9 μg/cm2, but the loading still remains thickness independent. Using phosphate buffered saline at 37 °C, less than 60% of the loaded mitoxantrone is readily released from the mesoporous carbon films over a two-week period. The release profile includes an initial burst with a modest fraction (<20%) of the loaded drug released within the first day, followed by a near linear release over the subsequent 5-9 days. Interestingly, the smaller pores (ca. 2 nm) release nearly 50% more mitoxantrone over 2 weeks than the larger pores (ca. 5 nm), despite the lower initial loading. These results illustrate potential limitations as well as opportunities for the use of highly hydrophobic porous materials for the controlled release of hydrophobic biologically active compounds as drug delivery systems.
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U2 - 10.1016/j.micromeso.2012.05.003
DO - 10.1016/j.micromeso.2012.05.003
M3 - Article
AN - SCOPUS:84861816372
SN - 1387-1811
VL - 160
SP - 143
EP - 150
JO - Microporous and Mesoporous Materials
JF - Microporous and Mesoporous Materials
ER -