@article{a4a5f369e0e14844a32fd569cfd26d2b,
title = "Slowed information processing in HIV-1 disease",
abstract = "This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV- positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.",
author = "Llorente, {Antolin M.} and Miller, {Eric N.} and D'Elia, {Louis F.} and Selnes, {Ola A.} and Jerry Wesch and Becker, {James T.} and Paul Satz",
note = "Funding Information: * The Multicenter AIDS Cohort Study (MACS) includes the following investigators: The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD: Alfred J. Saah, Principal Investigator; Haroutune Armenian, Homayoon Farzadegan, Neil Graham, Nancy Kass, Joseph Margolick, Justin McArthur, Ellen Taylor; Howard Brown Health Center-Northwestern University Medical School, Chicago, IL: John P. Phair, Principal Investigator; Joan S. Chmiel, Bruce Cohen, Maurice O{\textquoteright}Gorman, Daina Variakojis, Jerry Wesch, Steven M. Wolinsky; University of California, Schools of Public Health and Medicine, Los Angeles, CA: Roger Detels, Principal Investigator; Barbara R. Visscher, Janice P. Dudley, John L. Fahey, Janis V. Giorgi, Andrew Kaplan, Oto Martinez-Maza, Eric N. Miller, Hal Morgenstern, Parunag Nishanian, John Oishi, Jeremy Taylor, Harry Vinters, Jerome Zack; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA: Charles R. Rinaldo, Principal Investigator; Lawrence Kingsley, James T. Becker, Phalguni Gupta, John Mellors, Anthony Silvestre, Roger Anderson, Sharon Zucconi; The Johns Hopkins School of Hygiene and Public Health-Data Coordinating Center, Baltimore, MD: Alvaro Mu{\~n}oz, Principal Investigator; Cheryl Enger, Stephen Gange, Donald R. Hoover, Lisa P. Jacobson, Robert Lyles, Steven Piantadosi, Sol Su; National Institute of Allergy and Infectious Diseases-National Institutes of Health, Bethesda, MD: Lewis Schrager, Project Officer; National Cancer Institute, Bethesda, MD: Daniela Seminara. This research was supported by National Institutes of Health contracts No. U01-AI-35039, 35040, 35041, 35042, 35043, a grant (No. TW00003-07) from the University of California, Los Angeles UCLA/CIRID-Fogarty AIDS International Foundation to Antolin M. Llorente, and a National Institute of Health Training Grant (No. 4-484700-312788) to Paul Satz. Address correspondence to: Antolin M. Llorente, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-2399, USA. E-mail: llorente@bcm.tmc.edu. Accepted for publication: September 17, 1997",
year = "1998",
doi = "10.1076/jcen.20.1.60.1489",
language = "English (US)",
volume = "20",
pages = "60--72",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "1380-3395",
publisher = "Psychology Press Ltd",
number = "1",
}
