TY - JOUR
T1 - Slowed information processing in HIV-1 disease
AU - Llorente, Antolin M.
AU - Miller, Eric N.
AU - D'Elia, Louis F.
AU - Selnes, Ola A.
AU - Wesch, Jerry
AU - Becker, James T.
AU - Satz, Paul
N1 - Funding Information:
* The Multicenter AIDS Cohort Study (MACS) includes the following investigators: The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD: Alfred J. Saah, Principal Investigator; Haroutune Armenian, Homayoon Farzadegan, Neil Graham, Nancy Kass, Joseph Margolick, Justin McArthur, Ellen Taylor; Howard Brown Health Center-Northwestern University Medical School, Chicago, IL: John P. Phair, Principal Investigator; Joan S. Chmiel, Bruce Cohen, Maurice O’Gorman, Daina Variakojis, Jerry Wesch, Steven M. Wolinsky; University of California, Schools of Public Health and Medicine, Los Angeles, CA: Roger Detels, Principal Investigator; Barbara R. Visscher, Janice P. Dudley, John L. Fahey, Janis V. Giorgi, Andrew Kaplan, Oto Martinez-Maza, Eric N. Miller, Hal Morgenstern, Parunag Nishanian, John Oishi, Jeremy Taylor, Harry Vinters, Jerome Zack; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA: Charles R. Rinaldo, Principal Investigator; Lawrence Kingsley, James T. Becker, Phalguni Gupta, John Mellors, Anthony Silvestre, Roger Anderson, Sharon Zucconi; The Johns Hopkins School of Hygiene and Public Health-Data Coordinating Center, Baltimore, MD: Alvaro Muñoz, Principal Investigator; Cheryl Enger, Stephen Gange, Donald R. Hoover, Lisa P. Jacobson, Robert Lyles, Steven Piantadosi, Sol Su; National Institute of Allergy and Infectious Diseases-National Institutes of Health, Bethesda, MD: Lewis Schrager, Project Officer; National Cancer Institute, Bethesda, MD: Daniela Seminara. This research was supported by National Institutes of Health contracts No. U01-AI-35039, 35040, 35041, 35042, 35043, a grant (No. TW00003-07) from the University of California, Los Angeles UCLA/CIRID-Fogarty AIDS International Foundation to Antolin M. Llorente, and a National Institute of Health Training Grant (No. 4-484700-312788) to Paul Satz. Address correspondence to: Antolin M. Llorente, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-2399, USA. E-mail: [email protected]. Accepted for publication: September 17, 1997
PY - 1998
Y1 - 1998
N2 - This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV- positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.
AB - This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV- positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.
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U2 - 10.1076/jcen.20.1.60.1489
DO - 10.1076/jcen.20.1.60.1489
M3 - Article
C2 - 9672820
AN - SCOPUS:0031847473
SN - 1380-3395
VL - 20
SP - 60
EP - 72
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 1
ER -
