Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

Keyphrases

• Amyotrophic Lateral Sclerosis 100%
• Locomotor 100%
• RNA Recognition Motif 100%
• Drosophila Model 100%
• TAR DNA-binding Protein 43 (TDP-43) 100%
• Neurodegenerative Diseases 20%
• Motor Neuron 20%
• Small Molecules 10%
• Overexpression 10%
• DNA-binding Proteins 10%
• Transactivity 10%
• RNA-protein Interaction 10%
• Membrane-less 10%
• RRM2 10%
• Disease Pathogenesis 10%
• Hexanucleotide 10%
• RRM1 10%
• Stress Granules 10%
• Chemical Biology 10%
• Fly Model 10%
• Pathogenic Interaction 10%
• C9ORF72 Gene 10%
• In Silico Docking 10%
• Amyloid-like 10%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• RNA Recognition Motif 100%
• Fruit Fly Model 100%
• Transactive Response Dna Binding Protein-43 100%
• Transfer RNA 100%
• RNA 44%
• Motor Neuron 22%
• RNA-binding Protein 11%
• RRM2 11%
• RRM1 11%
• Stress Granule 11%
• TAR DNA Binding Protein 11%
• DNA-binding Protein 11%
• Amyloid Protein 11%
• C9orf72 11%

Neuroscience

• Transfer RNA 100%
• Amyotrophic Lateral Sclerosis 100%
• RNA Recognition Motif 100%
• Neurodegenerative Disorder 50%
• Neuromuscular 25%
• Amyloid Protein 25%
• DNA-binding Protein 25%
• TAR DNA Binding Protein 25%
• Protein RNA Binding 25%
• RNA-binding Protein 25%