Solid phase deprotection of 2-nitrobenzenesulfonamides: Synthesis of simple 2-(alkylamino)-pyrroles

Michael De Rosa; Nicola Stepani; Todd Cole; Jaclyn Fried; Lisa Huang-Pang; Lori Peacock; Michael Pro

doi:10.1016/j.tetlet.2005.06.082

Solid phase deprotection of 2-nitrobenzenesulfonamides: Synthesis of simple 2-(alkylamino)-pyrroles

Michael De Rosa, Nicola Stepani, Todd Cole, Jaclyn Fried, Lisa Huang-Pang, Lori Peacock, Michael Pro

Penn State Brandywine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The 2-nitrobenzenesulfonamide cleavage using a solid-phase thiophenolate reagent gives simple 2-(alkylamino)-pyrroles without the presence of the competing nucleophilic substitution product.

Original language	English (US)
Pages (from-to)	5715-5717
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2005.06.082
State	Published - Aug 22 2005

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.06.082

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@article{2a327b876ce54ef7b44e3e2a7656d1cc,

title = "Solid phase deprotection of 2-nitrobenzenesulfonamides: Synthesis of simple 2-(alkylamino)-pyrroles",

abstract = "The 2-nitrobenzenesulfonamide cleavage using a solid-phase thiophenolate reagent gives simple 2-(alkylamino)-pyrroles without the presence of the competing nucleophilic substitution product.",

author = "{De Rosa}, Michael and Nicola Stepani and Todd Cole and Jaclyn Fried and Lisa Huang-Pang and Lori Peacock and Michael Pro",

note = "Funding Information: This work was supported by grants from the National Science Foundation. We thank Dr. J. Honovich (Drexel University) for mass spectra.",

year = "2005",

month = aug,

day = "22",

doi = "10.1016/j.tetlet.2005.06.082",

language = "English (US)",

volume = "46",

pages = "5715--5717",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "34",

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TY - JOUR

T1 - Solid phase deprotection of 2-nitrobenzenesulfonamides

T2 - Synthesis of simple 2-(alkylamino)-pyrroles

AU - De Rosa, Michael

AU - Stepani, Nicola

AU - Cole, Todd

AU - Fried, Jaclyn

AU - Huang-Pang, Lisa

AU - Peacock, Lori

AU - Pro, Michael

N1 - Funding Information: This work was supported by grants from the National Science Foundation. We thank Dr. J. Honovich (Drexel University) for mass spectra.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - The 2-nitrobenzenesulfonamide cleavage using a solid-phase thiophenolate reagent gives simple 2-(alkylamino)-pyrroles without the presence of the competing nucleophilic substitution product.

AB - The 2-nitrobenzenesulfonamide cleavage using a solid-phase thiophenolate reagent gives simple 2-(alkylamino)-pyrroles without the presence of the competing nucleophilic substitution product.

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U2 - 10.1016/j.tetlet.2005.06.082

DO - 10.1016/j.tetlet.2005.06.082

M3 - Article

AN - SCOPUS:22544463625

SN - 0040-4039

VL - 46

SP - 5715

EP - 5717

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Solid phase deprotection of 2-nitrobenzenesulfonamides: Synthesis of simple 2-(alkylamino)-pyrroles

Abstract

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