Somatic INK4a-ARF locus mutations: A significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck

Keyphrases

• Head-and-neck 100%
• Ink4a 100%
• Squamous Cell Carcinoma of Head 100%
• Gene Inactivation 100%
• P16INK4a 100%
• Exon 1 50%
• P14ARF 50%
• Tumor Suppressor Gene 37%
• Somatic mutation 37%
• Gene Products 25%
• Sequence Modification 25%
• Exon 2 25%
• Single-strand Conformation Polymorphism 25%
• Somatic Alterations 25%
• Polymorphism Analysis 12%
• Highly Sensitive 12%
• Polymorphism 12%
• Exon 12%
• Functional Traits 12%
• Polymerase Chain Reaction 12%
• Tumor Suppressor 12%
• Mammalian Cells 12%
• Mutant Protein 12%
• Single nucleotide Variant 12%
• G1 Arrest 12%
• Human Chromosomes 12%
• Loss Function 12%
• Codon 12%
• Gene Deletion 12%
• Microdeletion 12%
• Cyclin-dependent Kinase 4 (CDK4) 12%
• Mutational Status 12%
• Negative Regulator 12%
• Total Loss 12%
• Non-radioactive 12%
• Gene Methylation 12%
• Cyclin-dependent Kinase 6 (CDK6) 12%
• Primary Squamous Cell Carcinoma 12%
• Reduced Function 12%

Biochemistry, Genetics and Molecular Biology

• Exon 100%
• Gene Inactivation 100%
• P14arf 80%
• Tumor Suppressor Gene 60%
• Somatic Mutation 60%
• Intron 40%
• Gene Mutation 40%
• Gene Product 40%
• Cyclin-Dependent Kinase 4 40%
• Wild Type 20%
• Promoter Region 20%
• Cell Cycle 20%
• Mutant Protein 20%
• Gene Deletion 20%
• Tumor Suppressor Protein 20%
• P53 20%
• G1/S Transition 20%
• Codon 20%
• Human Chromosome 20%