Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Deshu Zhuang, Jialong Han, Liangjia Bi, Yueping Wang, Yanru Hao, Qi Zhou, Wenwu Cao

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives: The aim of this study was to perform a histological evaluation of sonodynamic therapy (SDT) of hematoporphyrin monomethyl ether (HMME) on artificially induced periodontal disease in rats. Methods: Submerging ligatures were placed at the subgingival region of the first maxillary molar in rats. Eighty rats were randomly assigned into four groups: group 1 received no treatment; group 2 was subjected to 50 μg/mL HMME alone; group 3 was treated with low-intensity ultrasound alone (1 W/cm2); and group 4 was treated with 50 μg/mL HMME plus ultrasound irradiation (1 MHz, 30 minutes). Ten rats in each group were euthanized at 7 and 15 days, and periodontal tissue samples were taken for histological examination. Results: The animals treated by SDT showed less bone loss (P<0.05) at all experimental periods than the other three groups. No significant differences were found between the control and HMME groups (P>0.05). Conclusion: Our results suggest that HMME-mediated SDT can effectively alleviate the periodontal tissue destruction in artificially induced periodontitis in rats. Hence, SDT may have good clinic potential as a noninvasive treatment of periodontal diseases.

Original languageEnglish (US)
Pages (from-to)2545-2551
Number of pages7
JournalDrug Design, Development and Therapy
StatePublished - Apr 6 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery


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