TY - JOUR
T1 - Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model
AU - Gao, Zhongxiuzi
AU - Zheng, Jinhua
AU - Yang, Bin
AU - Wang, Zhu
AU - Fan, Haixia
AU - Lv, Yanhong
AU - Li, Haixia
AU - Jia, Limin
AU - Cao, Wenwu
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (No. 81272503 ) and the Scientific and Technical Key Tasks of Heilongjiang Province, China ( GC10C306 ).
PY - 2013/7/10
Y1 - 2013/7/10
N2 - Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT.
AB - Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT.
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U2 - 10.1016/j.canlet.2013.02.006
DO - 10.1016/j.canlet.2013.02.006
M3 - Article
C2 - 23402818
AN - SCOPUS:84878446775
SN - 0304-3835
VL - 335
SP - 93
EP - 99
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
