TY - JOUR
T1 - Sources of disconnection in neurocognitive aging
T2 - cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume
AU - Madden, David J.
AU - Parks, Emily L.
AU - Tallman, Catherine W.
AU - Boylan, Maria A.
AU - Hoagey, David A.
AU - Cocjin, Sally B.
AU - Packard, Lauren E.
AU - Johnson, Micah A.
AU - Chou, Ying hui
AU - Potter, Guy G.
AU - Chen, Nan kuei
AU - Siciliano, Rachel E.
AU - Monge, Zachary A.
AU - Honig, Jesse A.
AU - Diaz, Michele T.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
AB - Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
UR - https://www.scopus.com/pages/publications/85017394602
UR - https://www.scopus.com/inward/citedby.url?scp=85017394602&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2017.01.027
DO - 10.1016/j.neurobiolaging.2017.01.027
M3 - Article
C2 - 28389085
AN - SCOPUS:85017394602
SN - 0197-4580
VL - 54
SP - 199
EP - 213
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -