@article{5fc3c60df55746bfb8902d2aa231c2a5,
title = "SPARCL1 suppresses metastasis in prostate cancer",
abstract = "Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used invitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis invivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation invitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness invitro and tumor metastatic growth invivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first invivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.",
author = "Yuzhu Xiang and Qingchao Qiu and Ming Jiang and Renjie Jin and Lehmann, {Brian D.} and Strand, {Douglas W.} and Bojana Jovanovic and DeGraff, {David J.} and Yi Zheng and Yousif, {Dina A.} and Simmons, {Christine Q.} and Case, {Thomas C.} and Jia Yi and Cates, {Justin M.} and John Virostko and Xiusheng He and Xunbo Jin and Hayward, {Simon W.} and Matusik, {Robert J.} and George, {Alfred L.} and Yajun Yi",
note = "Funding Information: Grant Support: This work was supported in part by a Howard Temin Award from the National Cancer Institute at the National Institutes of Health ( CA114033 to YY), American Cancer Society-Institutional Research Grant (# IRG-58-009-51 and # IRG-58-009-53 ), and the Vanderbilt Clinical and Translational Science Awards (CTSA) UL1 RR024975 from National Center for Research Resources (NCRR) , a part of the National Institutes of Health (NIH) , ( CRC1838 to YY), and the National Cancer Institute ( 4R01-CA076142-14 to RJM ). DJD was supported by the American Cancer Society Great Lakes Division-Michigan Cancer Research Fund Postdoctoral Fellowship . The authors thank Dr. Harold L Moses and Dr. Jennifer Pietenpol for assistance in experiments; Dr. K. Pienta for providing bioluminescent human prostate carcinoma cell line (PC3-Luc); The Vanderbilt Cooperative Human Tissue Network for human tissue samples. Appendix A ",
year = "2013",
month = dec,
doi = "10.1016/j.molonc.2013.07.008",
language = "English (US)",
volume = "7",
pages = "1019--1030",
journal = "Molecular Oncology",
issn = "1574-7891",
publisher = "Elsevier",
number = "6",
}