Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

Changya Chen; Wenbao Yu; Joanna Tober; Peng Gao; Bing He; Kiwon Lee; Tuan Trieu; Gerd A. Blobel; Nancy A. Speck; Kai Tan

doi:10.1016/j.celrep.2019.11.065

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

Changya Chen
, Wenbao Yu
, Joanna Tober
, Peng Gao
, Bing He
, Kiwon Lee
, Tuan Trieu
, Gerd A. Blobel
, Nancy A. Speck
, Kai Tan

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.

Original language	English (US)
Pages (from-to)	4200-4211.e7
Journal	Cell Reports
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.11.065
State	Published - Dec 17 2019

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.11.065

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title = "Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells",

abstract = "A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.",

author = "Changya Chen and Wenbao Yu and Joanna Tober and Peng Gao and Bing He and Kiwon Lee and Tuan Trieu and Blobel, \{Gerd A.\} and Speck, \{Nancy A.\} and Kai Tan",

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doi = "10.1016/j.celrep.2019.11.065",

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T1 - Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

AU - Chen, Changya

AU - Yu, Wenbao

AU - Tober, Joanna

AU - Gao, Peng

AU - He, Bing

AU - Lee, Kiwon

AU - Trieu, Tuan

AU - Blobel, Gerd A.

AU - Speck, Nancy A.

AU - Tan, Kai

PY - 2019/12/17

Y1 - 2019/12/17

N2 - A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.

AB - A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.

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UR - https://www.scopus.com/pages/publications/85076379242#tab=citedBy

U2 - 10.1016/j.celrep.2019.11.065

DO - 10.1016/j.celrep.2019.11.065

M3 - Article

C2 - 31851943

AN - SCOPUS:85076379242

SN - 2211-1247

VL - 29

SP - 4200-4211.e7

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

Abstract

All Science Journal Classification (ASJC) codes

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