Spatiotemporal regulation of store-operated calcium entry in cancer metastasis

Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.

Original languageEnglish (US)
Pages (from-to)2581-2589
Number of pages9
JournalBiochemical Society transactions
Issue number6
StatePublished - Dec 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry


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