Abstract
We evaluated a patient for dyspnea, fever, malaise, and hypoxemia that developed after exposure to diphenylmethane diisocyanate (MDI). Specific inhalation challenge with MDI caused fever, leukocytosis, a restrictive decline in forced vital capacity, and a decrease in Pa(O2) several hours after challenge. Bronchoalveolar lavage 24 h after challenge showed lymphocytic alveolitis. Specific IgG antibodies to MDI human serum albumin (MDI-HSA) conjugate were demonstrated in serum and bronchial lavage fluid using the enzyme-linked immunoabsorbent (ELISA) technique. These findings suggest participation of both humoral and cellular immunity in the pathogenesis of hypersensitivity pneumonitis from isocyanate exposure.
Original language | English (US) |
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Pages (from-to) | 463-465 |
Number of pages | 3 |
Journal | American Review of Respiratory Disease |
Volume | 131 |
Issue number | 3 |
State | Published - 1985 |
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine