Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression

Michael R. Nonnemacher; Bryan P. Irish; Yujie Liu; David Mauger; Brian Wigdahl

doi:10.1016/j.jneuroim.2004.08.021

Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression

Michael R. Nonnemacher
, Bryan P. Irish
, Yujie Liu
, David Mauger
, Brian Wigdahl

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.

Original language	English (US)
Pages (from-to)	39-47
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	157
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jneuroim.2004.08.021
State	Published - Dec 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2004.08.021

Cite this

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title = "Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression",

abstract = "Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.",

author = "Nonnemacher, \{Michael R.\} and Irish, \{Bryan P.\} and Yujie Liu and David Mauger and Brian Wigdahl",

note = "Funding Information: The authors would like to thank Dr. Tricia Burdo (Scripps Research Institute) for her advice. These studies were supported by the United States Public Health Service/National Institutes of Health (USPHS/NIH NS67768, NS32092, NS27415 awarded to B. Wigdahl).",

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doi = "10.1016/j.jneuroim.2004.08.021",

language = "English (US)",

volume = "157",

pages = "39--47",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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AU - Nonnemacher, Michael R.

AU - Irish, Bryan P.

AU - Liu, Yujie

AU - Mauger, David

AU - Wigdahl, Brian

N1 - Funding Information: The authors would like to thank Dr. Tricia Burdo (Scripps Research Institute) for her advice. These studies were supported by the United States Public Health Service/National Institutes of Health (USPHS/NIH NS67768, NS32092, NS27415 awarded to B. Wigdahl).

PY - 2004/12

Y1 - 2004/12

N2 - Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.

AB - Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.

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U2 - 10.1016/j.jneuroim.2004.08.021

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AN - SCOPUS:9644266837

SN - 0165-5728

VL - 157

SP - 39

EP - 47

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2 SPEC. ISS.

ER -

Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression

Abstract

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