TY - JOUR
T1 - Spectral hole burning for ultrasound-modulated optical tomography of thick tissue
AU - Xu, Xiao
AU - Kothapalli, Sri Rajasekhar
AU - Liu, Honglin
AU - Wang, Lihong V.
N1 - Funding Information:
We are thankful to Chulhong Kim for his assistance with an early system setup. This research is funded in part by the National Institutes of Health grants R01 EB000712 and U54 CA136398.
PY - 2010/11
Y1 - 2010/11
N2 - We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm3+:YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.
AB - We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm3+:YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.
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U2 - 10.1117/1.3505486
DO - 10.1117/1.3505486
M3 - Article
C2 - 21198192
AN - SCOPUS:79955979495
SN - 1083-3668
VL - 15
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 6
M1 - 066018
ER -