TY - JOUR
T1 - Spectrin expression in neuroblastoma cells
AU - Goodman, Steven R.
AU - Zagon, Ian S.
AU - Coleman, Diane B.
AU - McLaughlin, Patricia J.
PY - 1986/5
Y1 - 1986/5
N2 - Mouse neuroblastoma cells express a spectrin-related molecule containing 240 kDal (kiloDalton) and 235 kDal subunits in a 1:1 ratio. The 240 kDal and 235 kDal subunits are nearly identical to the α and β subunits respectively of brain spectrin by two dimensional chymotryptic peptide mapping analysis. The neuroblastoma cells do not express a measureable quantity of a red blood cell (rbc)-type spectrin molecule. Neuroblastoma spectrin has been localized throughout the cell body, and neurites of these cells by indirect immunofluorescence studies. As neuroblastoma cells are homogenous, neuron-like, available in large quantity, and synthesize a single variant of spectrin which is closely related to brain spectrin( 240 235), it is the best available model system for the study of the synthesis, assembly and turnover of a neuronal spectrin subtype.
AB - Mouse neuroblastoma cells express a spectrin-related molecule containing 240 kDal (kiloDalton) and 235 kDal subunits in a 1:1 ratio. The 240 kDal and 235 kDal subunits are nearly identical to the α and β subunits respectively of brain spectrin by two dimensional chymotryptic peptide mapping analysis. The neuroblastoma cells do not express a measureable quantity of a red blood cell (rbc)-type spectrin molecule. Neuroblastoma spectrin has been localized throughout the cell body, and neurites of these cells by indirect immunofluorescence studies. As neuroblastoma cells are homogenous, neuron-like, available in large quantity, and synthesize a single variant of spectrin which is closely related to brain spectrin( 240 235), it is the best available model system for the study of the synthesis, assembly and turnover of a neuronal spectrin subtype.
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U2 - 10.1016/0361-9230(86)90133-4
DO - 10.1016/0361-9230(86)90133-4
M3 - Article
C2 - 2427173
AN - SCOPUS:0022482888
SN - 0361-9230
VL - 16
SP - 597
EP - 602
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 5
ER -