Spectrin subtypes in mammalian brain

Steven R. Goodman, Beat M. Riederer, Lan S. Zagon

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Mammalian neural cells contain at least two forms of brain spectrin: brain spectrin (240/235) which is located primarily in the axons and presynaptic terminals of neurons, and brain spectrin (240/235E) which is found in the cell bodies, dendrites and postsynaptic terminals of neurones. Brain spectrin (240/235E) is also found in certain glial cell types. Antibodies against red blood cell spectrin detect only brain spectrin (240/235E), while antibodies against brain spectrin isolated from axonal and synaptic membranes detect brain spectrin (240/235). Previous apparent discrepancies in the literature concerning brain spectrin localization at the light microscope level were undoubtedly due to different laboratories detecting distinct brain spectrin subtypes, based on the particular antibody being utilized for immunohistochemistry. In this review we (1) discuss the data supporting the presence of at least two distinct subtypes of mammalian brain spectrin, (2) explain how these results reconcile previous discrepancies concerning the localization of spectrin within neural cells, and (3) suggest the future implications of these findings.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
Issue number1
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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