Spectrin: The ghost in the machine

Graham H. Thomas

doi:10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1

Spectrin: The ghost in the machine

Graham H. Thomas

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane domains, recent genetic evidence indicates that this activity is not necessary for the establishment or maintenance of this axis. Instead, these studies point to critical roles in tissue stability and morphogenesis. A possible role in cellular contractility is highlighted in this review. BioEssays 23:152-160, 2001.

Original language	English (US)
Pages (from-to)	152-160
Number of pages	9
Journal	BioEssays
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1
State	Published - 2001

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1

Cite this

@article{c3319d00b3124a498e137ccf702c06cd,

title = "Spectrin: The ghost in the machine",

abstract = "It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane domains, recent genetic evidence indicates that this activity is not necessary for the establishment or maintenance of this axis. Instead, these studies point to critical roles in tissue stability and morphogenesis. A possible role in cellular contractility is highlighted in this review. BioEssays 23:152-160, 2001.",

author = "Thomas, {Graham H.}",

year = "2001",

doi = "10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1",

language = "English (US)",

volume = "23",

pages = "152--160",

journal = "BioEssays",

issn = "0265-9247",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Spectrin

T2 - The ghost in the machine

AU - Thomas, Graham H.

PY - 2001

Y1 - 2001

N2 - It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane domains, recent genetic evidence indicates that this activity is not necessary for the establishment or maintenance of this axis. Instead, these studies point to critical roles in tissue stability and morphogenesis. A possible role in cellular contractility is highlighted in this review. BioEssays 23:152-160, 2001.

AB - It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane domains, recent genetic evidence indicates that this activity is not necessary for the establishment or maintenance of this axis. Instead, these studies point to critical roles in tissue stability and morphogenesis. A possible role in cellular contractility is highlighted in this review. BioEssays 23:152-160, 2001.

UR - http://www.scopus.com/inward/record.url?scp=0035143853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035143853&partnerID=8YFLogxK

U2 - 10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1

DO - 10.1002/1521-1878(200102)23:2<152::AID-BIES1022>3.0.CO;2-1

M3 - Review article

C2 - 11169588

AN - SCOPUS:0035143853

SN - 0265-9247

VL - 23

SP - 152

EP - 160

JO - BioEssays

JF - BioEssays

IS - 2

ER -

Spectrin: The ghost in the machine

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this