Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules

Riqiang Fu; Richard L. Gill; Edward Y. Kim; Nicole E. Briley; Erin R. Tyndall; Jie Xu; Conggang Li; Kumaran S. Ramamurthi; John M. Flanagan; Fang Tian

doi:10.1021/jacs.5b08303

Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules

Riqiang Fu, Richard L. Gill, Edward Y. Kim, Nicole E. Briley, Erin R. Tyndall, Jie Xu, Conggang Li, Kumaran S. Ramamurthi, John M. Flanagan, Fang Tian

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

Original language	English (US)
Pages (from-to)	14031-14034
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	44
DOIs	https://doi.org/10.1021/jacs.5b08303
State	Published - Nov 11 2015

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules",

abstract = "Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.",

author = "Riqiang Fu and Gill, {Richard L.} and Kim, {Edward Y.} and Briley, {Nicole E.} and Tyndall, {Erin R.} and Jie Xu and Conggang Li and Ramamurthi, {Kumaran S.} and Flanagan, {John M.} and Fang Tian",

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AU - Fu, Riqiang

AU - Gill, Richard L.

AU - Kim, Edward Y.

AU - Briley, Nicole E.

AU - Tyndall, Erin R.

AU - Xu, Jie

AU - Li, Conggang

AU - Ramamurthi, Kumaran S.

AU - Flanagan, John M.

AU - Tian, Fang

PY - 2015/11/11

Y1 - 2015/11/11

N2 - Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

AB - Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

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Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules

Abstract

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