Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Brian M. Barth; Weiyuan Wang; Paul T. Toran; Todd E. Fox; Charyguly Annageldiyev; Regina M. Ondrasik; Nicole R. Keasey; Timothy J. Brown; Viola G. Devine; Emily C. Sullivan; Andrea L. Cote; Vasiliki Papakotsi; Su Fern Tan; Sriram S. Shanmugavelandy; Tye G. Deering; David B. Needle; Stephan T. Stern; Junjia Zhu; Jason Liao; Aaron D. Viny; David J. Feith; Ross L. Levine; Hong Gang Wang; Thomas P. Loughran; Arati Sharma; Mark Kester; David F. Claxton

doi:10.1182/bloodadvances.2018021295

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. VinyDavid J. Feith, Ross L. Levine, Hong Gang Wang, Thomas P. Loughran, Arati Sharma, Mark Kester, David F. Claxton

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26 Scopus citations

Original language	English (US)
Pages (from-to)	2598-2603
Number of pages	6
Journal	Blood Advances
Volume	3
Issue number	17
DOIs	https://doi.org/10.1182/bloodadvances.2018021295
State	Published - Sep 10 2019

All Science Journal Classification (ASJC) codes

Hematology

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Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., Keasey, N. R., Brown, T. J., Devine, V. G., Sullivan, E. C., Cote, A. L., Papakotsi, V., Tan, S. F., Shanmugavelandy, S. S., Deering, T. G., Needle, D. B., Stern, S. T., Zhu, J., Liao, J., ... Claxton, D. F. (2019). Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia. Blood Advances, 3(17), 2598-2603. https://doi.org/10.1182/bloodadvances.2018021295

@article{30a7d6f452844a98ba01a524be16c1e9,

title = "Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia",

author = "Barth, {Brian M.} and Weiyuan Wang and Toran, {Paul T.} and Fox, {Todd E.} and Charyguly Annageldiyev and Ondrasik, {Regina M.} and Keasey, {Nicole R.} and Brown, {Timothy J.} and Devine, {Viola G.} and Sullivan, {Emily C.} and Cote, {Andrea L.} and Vasiliki Papakotsi and Tan, {Su Fern} and Shanmugavelandy, {Sriram S.} and Deering, {Tye G.} and Needle, {David B.} and Stern, {Stephan T.} and Junjia Zhu and Jason Liao and Viny, {Aaron D.} and Feith, {David J.} and Levine, {Ross L.} and Wang, {Hong Gang} and Loughran, {Thomas P.} and Arati Sharma and Mark Kester and Claxton, {David F.}",

note = "Funding Information: This work was funded in part by grants from the National Institutes of Health, National Cancer Institute (P01 CA171983 [M.K., T.P.L., and H.-G.W.] and K22 CA190674 [B.M.B.]), a Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA0087480) (R.L.L.), a National Institute of General Medical Sciences, University of New Hampshire COBRE Pilot Project Grant (P20 GM113131) (B.M.B.), the Bess Family Charitable Fund (T.P.L.), a generous anonymous donor (T.P.L.), the Penn State University Kiesendahl Family Endowed Leukemia Research Fund and the Kenneth Noel Memorial Fund (D.F.C.), and Pennsylvania Tobacco Settlement funds (M.K. and T.P.L.).",

year = "2019",

month = sep,

day = "10",

doi = "10.1182/bloodadvances.2018021295",

language = "English (US)",

volume = "3",

pages = "2598--2603",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "17",

}

Barth, BM, Wang, W, Toran, PT, Fox, TE, Annageldiyev, C, Ondrasik, RM, Keasey, NR, Brown, TJ, Devine, VG, Sullivan, EC, Cote, AL, Papakotsi, V, Tan, SF, Shanmugavelandy, SS, Deering, TG, Needle, DB, Stern, ST, Zhu, J , Liao, J, Viny, AD, Feith, DJ, Levine, RL, Wang, HG, Loughran, TP, Sharma, A, Kester, M & Claxton, DF 2019, 'Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia', Blood Advances, vol. 3, no. 17, pp. 2598-2603. https://doi.org/10.1182/bloodadvances.2018021295

TY - JOUR

T1 - Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

AU - Barth, Brian M.

AU - Wang, Weiyuan

AU - Toran, Paul T.

AU - Fox, Todd E.

AU - Annageldiyev, Charyguly

AU - Ondrasik, Regina M.

AU - Keasey, Nicole R.

AU - Brown, Timothy J.

AU - Devine, Viola G.

AU - Sullivan, Emily C.

AU - Cote, Andrea L.

AU - Papakotsi, Vasiliki

AU - Tan, Su Fern

AU - Shanmugavelandy, Sriram S.

AU - Deering, Tye G.

AU - Needle, David B.

AU - Stern, Stephan T.

AU - Zhu, Junjia

AU - Liao, Jason

AU - Viny, Aaron D.

AU - Feith, David J.

AU - Levine, Ross L.

AU - Wang, Hong Gang

AU - Loughran, Thomas P.

AU - Sharma, Arati

AU - Kester, Mark

AU - Claxton, David F.

N1 - Funding Information: This work was funded in part by grants from the National Institutes of Health, National Cancer Institute (P01 CA171983 [M.K., T.P.L., and H.-G.W.] and K22 CA190674 [B.M.B.]), a Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA0087480) (R.L.L.), a National Institute of General Medical Sciences, University of New Hampshire COBRE Pilot Project Grant (P20 GM113131) (B.M.B.), the Bess Family Charitable Fund (T.P.L.), a generous anonymous donor (T.P.L.), the Penn State University Kiesendahl Family Endowed Leukemia Research Fund and the Kenneth Noel Memorial Fund (D.F.C.), and Pennsylvania Tobacco Settlement funds (M.K. and T.P.L.).

PY - 2019/9/10

Y1 - 2019/9/10

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U2 - 10.1182/bloodadvances.2018021295

DO - 10.1182/bloodadvances.2018021295

M3 - Article

C2 - 31488436

AN - SCOPUS:85072193038

SN - 2473-9529

VL - 3

SP - 2598

EP - 2603

JO - Blood Advances

JF - Blood Advances

IS - 17

ER -

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

All Science Journal Classification (ASJC) codes

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