Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

Keyphrases

• Activity Level 8%
• AKT1 16%
• AKT2 100%
• AKT3 16%
• Enzymatic Activity 8%
• Mammalian Target of Rapamycin (mTOR) 100%
• Mitogenic Signaling 8%
• MRNA Expression 8%
• MRNA Level 25%
• Pharmacological Inhibitors 8%
• Phosphoinositide 3-kinase (PI3K) 100%
• PI3K-AKT-mTOR Pathway 25%
• Protein Expression 8%
• Protein Expression Level 8%
• Protein Level 16%
• Rapamycin 8%
• Regulatory Role 8%
• Signaling Pathway 8%
• Small Interfering RNA (siRNA) 25%
• Sphingosine Kinase 1 (SphK1) 100%
• Vascular Smooth muscle Cells 8%
• Wortmannin 8%

Biochemistry, Genetics and Molecular Biology

• AKT1 16%
• AKT2 100%
• Enzyme Activity 8%
• Isoform 8%
• Kinase 8%
• Lipid 8%
• Mammalian Target of Rapamycin 100%
• Messenger RNA 25%
• mRNA Expression Level 8%
• mTOR Signaling 16%
• Phosphotransferase 8%
• PI3K/AKT/mTOR Pathway 8%
• Platelet-Derived Growth Factor 41%
• Protein Expression 8%
• Protein Expression Level 8%
• Signal Transduction 25%
• Small Interfering RNA 16%
• Sphingosine Kinase 1 100%