Spinal cord lesions in a pediatric patient with chronic kidney disease and review of literature: Questions

Harmanpreet Tiwana; Himadri Patel; Sheila Asghar; Ashutosh Kumar; Michael Freeman

doi:10.1007/s00467-018-4137-6

Spinal cord lesions in a pediatric patient with chronic kidney disease and review of literature: Questions

Harmanpreet Tiwana, Himadri Patel, Sheila Asghar, Ashutosh Kumar, Michael Freeman

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	1033
Number of pages	1
Journal	Pediatric Nephrology
Volume	34
Issue number	6
DOIs	https://doi.org/10.1007/s00467-018-4137-6
State	Published - Jun 1 2019

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s00467-018-4137-6

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@article{93854bcaad9d455d924600c518728596,

title = "Spinal cord lesions in a pediatric patient with chronic kidney disease and review of literature: Questions",

author = "Harmanpreet Tiwana and Himadri Patel and Sheila Asghar and Ashutosh Kumar and Michael Freeman",

note = "Funding Information: A 14-year-old female with no significant past medical history presented with a 2-week history of generalized abdominal pain followed by bi-frontal headaches with nausea, vomiting, and blurred vision. Significant findings on examination included elevated blood pressure of 220/100 and tenderness to palpation over entire abdomen without guarding or rigidity. Neurological examination was unrevealing. Funduscopic examination showed cotton wool spots and Elschnig?s spots consistent with chronic and acute hypertension respectively. Initial laboratory studies demonstrated a creatinine of 1.74 which improved to 1.2?1.4 over the subsequent days. She was started on a continuous Nicardipine drip for initial therapy of her hypertension and was subsequently transitioned to a combination of amlodipine and carvedilol therapy. Her evaluation included a renal ultrasound which showed a right kidney which was 10.7?cm and a left kidney which was 8.6?cm in length with bilaterally decreased corticomedullary differentiation, computed tomography (CT) of the abdomen showed no evidence of renal artery stenosis, and an x-ray voiding cystourethrogram showed persistent grade 3 vesicoureteral reflux of the right renal collecting system and intermittent grade 3 reflux of the left renal collecting system. An echocardiogram demonstrated concentric left ventricular hypertrophy with a left ventricular mass index (LVMI) of 45.7. The day after presentation, she complained of intermittent numbness and tingling in her extremities with urinary retention and her neurologic examination revealed hyperreflexia with 5?6 beats bilateral ankle clonus. Magnetic resonance imaging (MRI) of the brain demonstrated subcortical white matter FLAIR hyperintensities, more pronounced in the bilateral parietal lobes and in bilateral anterior medulla oblongata (Fig.?1 a). Additionally, hyperintensity was noted in the cervical segment of spinal cord along with long segment abnormality involving the ventral thoracic cord (Fig. 1 b). Question 1.What would be the differential diagnosis based on clinical examination and MRI findings? 2.What would be the next step in evaluation? 3.What is the prognosis?",

year = "2019",

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doi = "10.1007/s00467-018-4137-6",

language = "English (US)",

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journal = "Pediatric Nephrology",

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T1 - Spinal cord lesions in a pediatric patient with chronic kidney disease and review of literature

T2 - Questions

AU - Tiwana, Harmanpreet

AU - Patel, Himadri

AU - Asghar, Sheila

AU - Kumar, Ashutosh

AU - Freeman, Michael

N1 - Funding Information: A 14-year-old female with no significant past medical history presented with a 2-week history of generalized abdominal pain followed by bi-frontal headaches with nausea, vomiting, and blurred vision. Significant findings on examination included elevated blood pressure of 220/100 and tenderness to palpation over entire abdomen without guarding or rigidity. Neurological examination was unrevealing. Funduscopic examination showed cotton wool spots and Elschnig?s spots consistent with chronic and acute hypertension respectively. Initial laboratory studies demonstrated a creatinine of 1.74 which improved to 1.2?1.4 over the subsequent days. She was started on a continuous Nicardipine drip for initial therapy of her hypertension and was subsequently transitioned to a combination of amlodipine and carvedilol therapy. Her evaluation included a renal ultrasound which showed a right kidney which was 10.7?cm and a left kidney which was 8.6?cm in length with bilaterally decreased corticomedullary differentiation, computed tomography (CT) of the abdomen showed no evidence of renal artery stenosis, and an x-ray voiding cystourethrogram showed persistent grade 3 vesicoureteral reflux of the right renal collecting system and intermittent grade 3 reflux of the left renal collecting system. An echocardiogram demonstrated concentric left ventricular hypertrophy with a left ventricular mass index (LVMI) of 45.7. The day after presentation, she complained of intermittent numbness and tingling in her extremities with urinary retention and her neurologic examination revealed hyperreflexia with 5?6 beats bilateral ankle clonus. Magnetic resonance imaging (MRI) of the brain demonstrated subcortical white matter FLAIR hyperintensities, more pronounced in the bilateral parietal lobes and in bilateral anterior medulla oblongata (Fig.?1 a). Additionally, hyperintensity was noted in the cervical segment of spinal cord along with long segment abnormality involving the ventral thoracic cord (Fig. 1 b). Question 1.What would be the differential diagnosis based on clinical examination and MRI findings? 2.What would be the next step in evaluation? 3.What is the prognosis?

PY - 2019/6/1

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JO - Pediatric Nephrology

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Spinal cord lesions in a pediatric patient with chronic kidney disease and review of literature: Questions

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