TY - JOUR
T1 - Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7
AU - Höpfl, Reinhard
AU - Heim, Kurt
AU - Christensen, Neil
AU - Zumbach, Klaus
AU - Wieland, Ulrike
AU - Volgger, Birgit
AU - Widschwendter, Andreas
AU - Haimbuchner, Sandra
AU - Müller-Holzner, Elisabeth
AU - Pawlita, Michael
AU - Pfister, Herbert
AU - Fritsch, Peter
N1 - Funding Information:
This study was partly supported by grant P-10896-MED of the Austrian Science Foundation. The first purchase of peptides was made possible by the European Concerted Action for HPV Immunology and Vaccine Development and the Austrian Krebsfonds.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2000/12/9
Y1 - 2000/12/9
N2 - We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides, 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
AB - We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides, 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
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U2 - 10.1016/S0140-6736(00)03315-8
DO - 10.1016/S0140-6736(00)03315-8
M3 - Article
C2 - 11130532
AN - SCOPUS:0034627197
SN - 0140-6736
VL - 356
SP - 1985
EP - 1986
JO - Lancet
JF - Lancet
IS - 9246
ER -
