Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7

Reinhard Höpfl, Kurt Heim, Neil Christensen, Klaus Zumbach, Ulrike Wieland, Birgit Volgger, Andreas Widschwendter, Sandra Haimbuchner, Elisabeth Müller-Holzner, Michael Pawlita, Herbert Pfister, Peter Fritsch

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides, 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.

Original languageEnglish (US)
Pages (from-to)1985-1986
Number of pages2
Issue number9246
StatePublished - Dec 9 2000

All Science Journal Classification (ASJC) codes

  • General Medicine


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