TY - JOUR
T1 - Standard conformations for the canonical structures of immunoglobulins
AU - Al-Lazikani, Bissan
AU - Lesk, Arthur M.
AU - Chothia, Cyrus
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1997/11/7
Y1 - 1997/11/7
N2 - A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2 hypervariable regions in 17 immunoglobulin structures that have been accurately determined at high resolution is described. This involves 79 hypervariable regions in all. We also analysed a part of the H3 region in 12 of the 15 V(H) domains considered here. On the basis of the residues at key sites the 79 hypervariable regions can be assigned to one of 18 different canonical structures. We show that 71 of these hypervariable regions have a conformation that is very close to what can be defined as a 'standard' conformation of each canonical structure. These standard conformations are described in detail. The other eight hypervariable regions have small deviations from the standard conformations that, in six cases, involve only the rotation of a single peptide group. Most H3 hypervariable regions have the same conformation in the part that is close to the framework and the details of this conformation are also described here.
AB - A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2 hypervariable regions in 17 immunoglobulin structures that have been accurately determined at high resolution is described. This involves 79 hypervariable regions in all. We also analysed a part of the H3 region in 12 of the 15 V(H) domains considered here. On the basis of the residues at key sites the 79 hypervariable regions can be assigned to one of 18 different canonical structures. We show that 71 of these hypervariable regions have a conformation that is very close to what can be defined as a 'standard' conformation of each canonical structure. These standard conformations are described in detail. The other eight hypervariable regions have small deviations from the standard conformations that, in six cases, involve only the rotation of a single peptide group. Most H3 hypervariable regions have the same conformation in the part that is close to the framework and the details of this conformation are also described here.
UR - http://www.scopus.com/inward/record.url?scp=0031558798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031558798&partnerID=8YFLogxK
U2 - 10.1006/jmbi.1997.1354
DO - 10.1006/jmbi.1997.1354
M3 - Article
C2 - 9367782
AN - SCOPUS:0031558798
SN - 0022-2836
VL - 273
SP - 927
EP - 948
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 4
ER -