Starvation results in decreased initiation factor activity in rat skeletal muscle

D. Eugene Rannels, Anthony E. Pegg, Stephen R. Rannels

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Activity of a factor forming a nitrocellulose filter-bound complex with [35S]met-tRNAmetf and GTP was estimated in the post-ribosomal supernatant of psoas and heart muscle. Complex formation required initiator tRNA and GTP or GMP-P(CH2)P; it was inhibited by Mg2+, GDP, aurintricarboxylic acid, spermine and spermidine. Starvation reduced complex-forming activity of supernatants from psoas but not heart muscle. Reduced activity was not due to increased dilution or deacylation of met-tRNAmetf or to increased hydrolysis of GTP by extracts from starved animals.

Original languageEnglish (US)
Pages (from-to)1481-1489
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Oct 18 1976

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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