TY - JOUR
T1 - State-of-the-art acute and chronic GVHD treatment
AU - Jamil, Muhammad Omer
AU - Mineishi, Shin
N1 - Publisher Copyright:
© 2015, The Japanese Society of Hematology.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Graft-versus-host disease (GVHD) remains as the major obstacle for successful hematopoietic stem cell transplant (HSCT). Roughly half of the patients undergoing HSCT develop GVHD which requires treatment, and above 10 % of the patient may die because of it. However, GVHD presents with anti-tumor activity, called graft-versus-tumor (GVT) effect, and it carries significant anti-tumor activity, thus suppressing GVHD completely may increase the relapse of original disease. Thus, it is important to control GVHD to the appropriate level.
AB - Graft-versus-host disease (GVHD) remains as the major obstacle for successful hematopoietic stem cell transplant (HSCT). Roughly half of the patients undergoing HSCT develop GVHD which requires treatment, and above 10 % of the patient may die because of it. However, GVHD presents with anti-tumor activity, called graft-versus-tumor (GVT) effect, and it carries significant anti-tumor activity, thus suppressing GVHD completely may increase the relapse of original disease. Thus, it is important to control GVHD to the appropriate level.
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U2 - 10.1007/s12185-015-1785-1
DO - 10.1007/s12185-015-1785-1
M3 - Review article
C2 - 25864189
AN - SCOPUS:84937764080
SN - 0925-5710
VL - 101
SP - 452
EP - 466
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -