TY - JOUR
T1 - Stereoselective separation and detection of phenoxy acid herbicide enantiomers by cyclodextrin-modified capillary zone electrophoresis-electrospray ionization mass spectrometry
AU - Otsuka, Koji
AU - Smith, Christopher J.
AU - Grainger, James
AU - Barr, John R.
AU - Patterson, Donald G.
AU - Tanaka, Nobuo
AU - Terabe, Shigeru
N1 - Funding Information:
This work was supported in part by the Grant-in-Aid for Scientific Research (No. 09640733) and the Joint Research program of the Grant-in-Aid for International Scientific Research (No. 09044081) from the Ministry of Education, Science, Sports and Culture, Japan. K.O. is grateful to Dr. Hiroto Ozaki (Kaneka Techno Research Co.), Mr. Yoshihide Tanaka (Nippon Boehringer Ingelheim Co.) and Ms. Kaho Minoura (Yokogawa Analytical Systems Inc.) for helpful discussions and advice for MS measurements. He also thanks Mr. Joselito P. Quirino (Himeji Institute of Technology) for technical assistance.
PY - 1998/8/21
Y1 - 1998/8/21
N2 - An application of on-line coupling of capillary electrophoresis and mass spectrometry (CE-MS) to the chiral separation of phenoxy acid herbicide enantiomers was investigated. As an ionization method, electrospray ionization (ESI) is used for a CE-MS interface. Generally, nonvolatile additives in separation solutions sometimes decrease the MS sensitivity and/or signal intensity. In this study, however, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD) was used as a chiral selector and it migrated directly into the ESI interface. By using the negative-ionization mode along with a methanol-water-formic acid solution as a sheath liquid and nitrogen as a sheath gas, stereoselective separation and detection of three phenoxy acid herbicide enantiomers were successfully achieved with a 20 mM TM-β-CD in a 50 mM ammonium acetate buffer (pH 4.6). Copyright (C) 1998 Elsevier Science B.V.
AB - An application of on-line coupling of capillary electrophoresis and mass spectrometry (CE-MS) to the chiral separation of phenoxy acid herbicide enantiomers was investigated. As an ionization method, electrospray ionization (ESI) is used for a CE-MS interface. Generally, nonvolatile additives in separation solutions sometimes decrease the MS sensitivity and/or signal intensity. In this study, however, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD) was used as a chiral selector and it migrated directly into the ESI interface. By using the negative-ionization mode along with a methanol-water-formic acid solution as a sheath liquid and nitrogen as a sheath gas, stereoselective separation and detection of three phenoxy acid herbicide enantiomers were successfully achieved with a 20 mM TM-β-CD in a 50 mM ammonium acetate buffer (pH 4.6). Copyright (C) 1998 Elsevier Science B.V.
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U2 - 10.1016/S0021-9673(98)00317-3
DO - 10.1016/S0021-9673(98)00317-3
M3 - Article
AN - SCOPUS:0032555754
SN - 0021-9673
VL - 817
SP - 75
EP - 81
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -