Stereoselective total synthesis of the antitumor antibiotic (-)-bactobolin

Ravi S. Garigipati; Steven M. Weinreb

doi:10.1021/jo00252a060

Stereoselective total synthesis of the antitumor antibiotic (-)-bactobolin

Ravi S. Garigipati, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The first total synthesis of the biologically active microbial metabolite bactobolin (2) has been achieved. An efficient, stereoselective route to 2 in 16 steps from previously prepared α-keto lactone 3 is outlined.

Original language	English (US)
Pages (from-to)	4143-4145
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	53
Issue number	17
DOIs	https://doi.org/10.1021/jo00252a060
State	Published - Aug 1 1988

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00252a060

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title = "Stereoselective total synthesis of the antitumor antibiotic (-)-bactobolin",

abstract = "The first total synthesis of the biologically active microbial metabolite bactobolin (2) has been achieved. An efficient, stereoselective route to 2 in 16 steps from previously prepared α-keto lactone 3 is outlined.",

author = "Garigipati, {Ravi S.} and Weinreb, {Steven M.}",

year = "1988",

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AU - Garigipati, Ravi S.

AU - Weinreb, Steven M.

PY - 1988/8/1

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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ER -

Stereoselective total synthesis of the antitumor antibiotic (-)-bactobolin

Abstract

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