TY - JOUR
T1 - Stereospecific modulation of tumorigenicity by opioid antagonists
AU - Zagon, Ian S.
AU - McLaughlin, Patricia J.
N1 - Funding Information:
This work was supported in part by NIH grants NS-20623 and NS-20500.
PY - 1985/7/11
Y1 - 1985/7/11
N2 - The effects of (+) and (-) isomers of naloxone in altering tumor response in A/Jax mice inoculated with S20Y neuroblastoma were determined. Mice given daily subcutaneous injections of 15 mg/kg (-)naloxone had a 71% tumor incidence, a 33% delay in the time before tumor appearance, and a 28% increase in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 13 days. Animals given 15 mg/kg (+)naloxone were comparable to control subjects in all aspects of neural neoplasia. These results show that opioid antagonists exert a stereospecific action on neural cancers, and provide further evidence that endogenous opioid systems play an important role in neuro-oncogenic expression.
AB - The effects of (+) and (-) isomers of naloxone in altering tumor response in A/Jax mice inoculated with S20Y neuroblastoma were determined. Mice given daily subcutaneous injections of 15 mg/kg (-)naloxone had a 71% tumor incidence, a 33% delay in the time before tumor appearance, and a 28% increase in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 13 days. Animals given 15 mg/kg (+)naloxone were comparable to control subjects in all aspects of neural neoplasia. These results show that opioid antagonists exert a stereospecific action on neural cancers, and provide further evidence that endogenous opioid systems play an important role in neuro-oncogenic expression.
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U2 - 10.1016/0014-2999(85)90350-4
DO - 10.1016/0014-2999(85)90350-4
M3 - Article
C2 - 2995053
AN - SCOPUS:0021934209
SN - 0014-2999
VL - 113
SP - 115
EP - 120
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -
