@article{f6c39a445c244add9145eb0619a08eaa,
title = "Stereospecificity of thymidylate synthetase",
abstract = "The stereospecific formation of the methyl group of thymidylate from uridylate and 5,10-methylene-tetrahydrofolate catalysed by thymidylate synthetase has been delineated.",
author = "Charles Tatum and John Vederas and Erwin Schleicher and Benkovic, {Stephen J.} and Heinz Floss",
note = "Funding Information: CHEM.COMM.,1977 addition product may cleave to the exo-methylene deri- vative (10) which stereospecifically accepts the 6-hydrogen (Hd) to produce thymidine monophosphate (5). With the present results and some reasonable assumptions, knowledge of the absolution configuration of 5,lO-methylenetetrahydro-folate (2)would predict the three-dimensional orientations of the reaction components on the surface of serine trans- hydroxymethylase and thymidylate synthetase. We thank NIH (H.G.F.) and NSF (S.J.B.) for financial support, Professor Eggerer for the gift of chiral acetate samples, and Professor Santi for a sample of thymidylate synthetase, and acknowledge the technical assistance of L. ",
year = "1977",
doi = "10.1039/C39770000218",
language = "English (US)",
pages = "218--220",
journal = "Journal of the Chemical Society, Chemical Communications",
issn = "0022-4936",
publisher = "Royal Society of Chemistry",
number = "7",
}