Stereotactic radiation therapy for oligometastases or oligorecurrence within mediastinal lymph nodes

Huan Huan Wang, Nicholas G. Zaorsky, Mao Bin Meng, Xian Liang Zeng, Lei Deng, Yong Chun Song, Hong Qing Zhuang, Feng Tong Li, Lu Jun Zhao, Zhi Yong Yuan, Ping Wang, Xi Shan Hao

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Aims: This study evaluated the safety and efficacy of stereotactic radiation therapy (SRT) for the treatment of patients with oligometastases or oligorecurrence within mediastinal lymph nodes (MLNs) originating from different tumors. Methods: Between October 2006 and May 2015, patients with MLN oligometastases or oligorecurrence were enrolled and treated with SRT at our hospital. The primary endpoint was MLN local control (LC). Secondary endpoints were time to symptom alleviation, overall survival (OS) after SRT, and toxicity using the Common Terminology Criteria for Adverse Events (CTCAE v4.0). Results: Eighty-five patients with 98 MLN oligometastases or oligorecurrences were treated with SRT. For the entire cohort, the 1-year and 5-year actuarial LC rates were 97% and 77%, respectively. Of 53 symptomatic patients, symptom alleviation was observed in 47 (89%) after a median of 5 days (range, 3-30 days). The median OS was 27.2 months for all patients. For patients with non-small cell lung cancer, univariate and multivariate analyses revealed that a shorter interval between diagnosis of primary tumors and SRT and larger MLN SRT volume were associated with worse OS. CTCAE v4.0 ≥ Grade 3 toxicities occurred in six patients (7%), with Grade 5 in three patients (all with RT history to MLN station 7). Conclusions: SRT is a safe and efficacious treatment modality for patients with oligometastases or oligorecurrence to MLNs originating from different tumors, except for patients who received radiotherapy to MLN station 7. Further investigation is warranted to identify the patients who benefit most from this treatment modality.

Original languageEnglish (US)
Pages (from-to)18135-18145
Number of pages11
Issue number14
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology


Dive into the research topics of 'Stereotactic radiation therapy for oligometastases or oligorecurrence within mediastinal lymph nodes'. Together they form a unique fingerprint.

Cite this