Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis

Keyphrases

• Amyloidogenesis 100%
• Stilbenes 100%
• Traceless 100%
• Transthyretin 100%
• Vinyl Sulfonamide 100%
• Fluorogenic Sensor 100%
• Vinyl 30%
• Amides 30%
• Biological Environment 30%
• Small Molecules 20%
• Conjugation 20%
• Fluorogenic 20%
• Chemoselectivity 20%
• X-ray 10%
• Binding Site 10%
• Dissociation 10%
• Amino Group 10%
• Leaving Group 10%
• Non-enzyme 10%
• Good Enough 10%
• Medicinal Chemistry 10%
• Background Fluorescence 10%
• Human Plasma 10%
• Binding Selectivity 10%
• Secondary Amines 10%
• PK a 10%
• Fluorescence Reader 10%
• E. Coli Lysate 10%
• Amyloid Fibrillation 10%
• 1,4-Michael Addition 10%
• Fluorogenicity 10%
• Enzyme Drug Target 10%
• Selectivity Enhancement 10%

Chemistry

• Chemical Kinetics Characteristics 100%
• Stilbene 100%
• Sulfonamide 100%
• stabilizer 100%
• Carboxamide 50%
• Chemoselectivity 33%
• formation 33%
• Chemistry 16%
• Binding Site 16%
• Amino Group 16%
• Dissociation Exponent 16%
• Michael Addition 16%
• Amyloid Fibril 16%
• Secondary Amine 16%
• Drug Target 16%