STIM and orai: Dynamic intermembrane coupling to control cellular calcium signals

Xiaoxiang Deng, Youjun Wang, Yandong Zhou, Jonathan Soboloff, Donald L. Gill

Research output: Contribution to journalShort surveypeer-review

103 Scopus citations


Ca2+ signals controlling a vast array of cell functions involve both Ca2+ store release and external Ca2+ entry. These two events are coordinated through a dynamic intermembrane coupling between two distinct membrane proteins, STIM and Orai. STIM proteins are endoplasmic reticulum (ER) luminal Ca2+ sensors that undergo a profound redistribution into discrete junctional ER domains closely juxtaposed with the plasma membrane (PM). Orai proteins are PM Ca2+ channels that migrate and become tethered by STIM within the ER-PM junctions, where they mediate exceedingly selective Ca2+ entry. We describe a new understanding of the nature of the proteins and how they function to mediate this remarkable intermembrane signaling process controlling Ca2+ signals.

Original languageEnglish (US)
Pages (from-to)22501-22505
Number of pages5
JournalJournal of Biological Chemistry
Issue number34
StatePublished - Aug 21 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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