Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

Anthony E. Pegg; Wayne Perry

doi:10.1093/carcin/2.11.1195

Stimulation of transfer of methyl groups from O⁶-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

Anthony E. Pegg, Wayne Perry

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O⁶-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.

Original language	English (US)
Pages (from-to)	1195-1200
Number of pages	6
Journal	Carcinogenesis
Volume	2
Issue number	11
DOIs	https://doi.org/10.1093/carcin/2.11.1195
State	Published - 1981

All Science Journal Classification (ASJC) codes

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/carcin/2.11.1195

Cite this

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title = "Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins",

abstract = "An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.",

author = "Pegg, {Anthony E.} and Wayne Perry",

note = "Funding Information: This research was supported in part by grant CA18137 from the National Cancer Institute.",

year = "1981",

doi = "10.1093/carcin/2.11.1195",

language = "English (US)",

volume = "2",

pages = "1195--1200",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

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T1 - Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

AU - Pegg, Anthony E.

AU - Perry, Wayne

N1 - Funding Information: This research was supported in part by grant CA18137 from the National Cancer Institute.

PY - 1981

Y1 - 1981

N2 - An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.

AB - An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.

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