Stochastic MPC design for a two-component granulation process

Negar Hashemian, Antonios Armaou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


We address the issue of control of a stochastic two-component granulation process in pharmaceutical applications through using Stochastic Model Predictive Control (SMPC) and model reduction to obtain the desired particle distribution. We first use the method of moments to reduce the governing integro-differential equation down to a nonlinear ordinary differential equation (ODE). This reduced-order model is employed in the SMPC formulation. The probabilistic constraints in this formulation keep the variance of particles' drug concentration in an admissible range. To solve the resulting stochastic optimization problem, we first employ polynomial chaos expansion to obtain the Probability Distribution Function (PDF) of the future state variables using the uncertain variables' distributions. As a result, the original stochastic optimization problem for a particulate system is converted to a deterministic dynamic optimization. This approximation lessens the computation burden of the controller and makes its real time application possible.

Original languageEnglish (US)
Title of host publication2017 American Control Conference, ACC 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages6
ISBN (Electronic)9781509059928
StatePublished - Jun 29 2017
Event2017 American Control Conference, ACC 2017 - Seattle, United States
Duration: May 24 2017May 26 2017

Publication series

NameProceedings of the American Control Conference
ISSN (Print)0743-1619


Other2017 American Control Conference, ACC 2017
Country/TerritoryUnited States

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering


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