Store-independent orai channels regulated by STIM

Xuexin Zhang, Maxime Gueguinou, M. Trebak

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations


The identication of Orai and STIM proteins has opened up new avenues of research in the eld of receptor-regulated calcium signaling. The ligation of phospholipase C (PLC)-coupled receptors can activate either the common store-operated calcium entry (SOCE) pathway or store-independent calcium entry (SICE) pathway. The representative conductance of the SOCE pathway is the calcium release-activated calcium (CRAC) channel encoded by Orai (CRACM) proteins. The SICE pathway biophysical manifestation is currents activated by arachidonic acid (AA) or the AA metabolite leukotriene C4 (LTC4) and termed arachidonate-regulated or LTC4-regulated calcium (ARC/LRC) current encoded by channels composed of both Orai1 and Orai3 proteins.

Original languageEnglish (US)
Title of host publicationCalcium Entry Channels in Non-Excitable Cells
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781498752732
ISBN (Print)9781498752725
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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