Store-independent orai channels regulated by STIM

Xuexin Zhang; Maxime Gueguinou; M. Trebak

doi:10.1201/9781315152592

Store-independent orai channels regulated by STIM

Xuexin Zhang, Maxime Gueguinou, M. Trebak

Research output: Chapter in Book/Report/Conference proceeding › Chapter

24 Scopus citations

Abstract

The identication of Orai and STIM proteins has opened up new avenues of research in the eld of receptor-regulated calcium signaling. The ligation of phospholipase C (PLC)-coupled receptors can activate either the common store-operated calcium entry (SOCE) pathway or store-independent calcium entry (SICE) pathway. The representative conductance of the SOCE pathway is the calcium release-activated calcium (CRAC) channel encoded by Orai (CRACM) proteins. The SICE pathway biophysical manifestation is currents activated by arachidonic acid (AA) or the AA metabolite leukotriene C4 (LTC4) and termed arachidonate-regulated or LTC4-regulated calcium (ARC/LRC) current encoded by channels composed of both Orai1 and Orai3 proteins.

Original language	English (US)
Title of host publication	Calcium Entry Channels in Non-Excitable Cells
Publisher	CRC Press
Pages	197-213
Number of pages	17
ISBN (Electronic)	9781498752732
ISBN (Print)	9781498752725
DOIs	https://doi.org/10.1201/9781315152592
State	Published - Jan 1 2017

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1201/9781315152592

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title = "Store-independent orai channels regulated by STIM",

abstract = "The identication of Orai and STIM proteins has opened up new avenues of research in the eld of receptor-regulated calcium signaling. The ligation of phospholipase C (PLC)-coupled receptors can activate either the common store-operated calcium entry (SOCE) pathway or store-independent calcium entry (SICE) pathway. The representative conductance of the SOCE pathway is the calcium release-activated calcium (CRAC) channel encoded by Orai (CRACM) proteins. The SICE pathway biophysical manifestation is currents activated by arachidonic acid (AA) or the AA metabolite leukotriene C4 (LTC4) and termed arachidonate-regulated or LTC4-regulated calcium (ARC/LRC) current encoded by channels composed of both Orai1 and Orai3 proteins.",

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T1 - Store-independent orai channels regulated by STIM

AU - Zhang, Xuexin

AU - Gueguinou, Maxime

AU - Trebak, M.

PY - 2017/1/1

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N2 - The identication of Orai and STIM proteins has opened up new avenues of research in the eld of receptor-regulated calcium signaling. The ligation of phospholipase C (PLC)-coupled receptors can activate either the common store-operated calcium entry (SOCE) pathway or store-independent calcium entry (SICE) pathway. The representative conductance of the SOCE pathway is the calcium release-activated calcium (CRAC) channel encoded by Orai (CRACM) proteins. The SICE pathway biophysical manifestation is currents activated by arachidonic acid (AA) or the AA metabolite leukotriene C4 (LTC4) and termed arachidonate-regulated or LTC4-regulated calcium (ARC/LRC) current encoded by channels composed of both Orai1 and Orai3 proteins.

AB - The identication of Orai and STIM proteins has opened up new avenues of research in the eld of receptor-regulated calcium signaling. The ligation of phospholipase C (PLC)-coupled receptors can activate either the common store-operated calcium entry (SOCE) pathway or store-independent calcium entry (SICE) pathway. The representative conductance of the SOCE pathway is the calcium release-activated calcium (CRAC) channel encoded by Orai (CRACM) proteins. The SICE pathway biophysical manifestation is currents activated by arachidonic acid (AA) or the AA metabolite leukotriene C4 (LTC4) and termed arachidonate-regulated or LTC4-regulated calcium (ARC/LRC) current encoded by channels composed of both Orai1 and Orai3 proteins.

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ER -

Store-independent orai channels regulated by STIM

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