Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

Jerome F. Strauss; Jennifer R. Wood; Lane K. Christenson; Jan M. McAllister

doi:10.1016/S0303-7207(01)00662-1

Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

Jerome F. Strauss, Jennifer R. Wood, Lane K. Christenson, Jan M. McAllister

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.

Original language	English (US)
Pages (from-to)	183-188
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	186
Issue number	2
DOIs	https://doi.org/10.1016/S0303-7207(01)00662-1
State	Published - Jan 25 2002

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Endocrinology

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10.1016/S0303-7207(01)00662-1

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title = "Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS",

abstract = "Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.",

author = "Strauss, {Jerome F.} and Wood, {Jennifer R.} and Christenson, {Lane K.} and McAllister, {Jan M.}",

note = "Funding Information: Supported by NIH grant HD34449, HD06274, HD07305 and HD33852.",

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AU - Strauss, Jerome F.

AU - Wood, Jennifer R.

AU - Christenson, Lane K.

AU - McAllister, Jan M.

N1 - Funding Information: Supported by NIH grant HD34449, HD06274, HD07305 and HD33852.

PY - 2002/1/25

Y1 - 2002/1/25

N2 - Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.

AB - Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.

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Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

Abstract

All Science Journal Classification (ASJC) codes

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