Stretching exercises - Flexibility in dihydrofolate reductase catalysis

Grover Paul Miller; Stephen J. Benkovic

doi:10.1016/S1074-5521(98)90616-0

Stretching exercises - Flexibility in dihydrofolate reductase catalysis

Grover Paul Miller, Stephen J. Benkovic

Chemistry

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

Original language	English (US)
Pages (from-to)	R105-R113
Journal	Chemistry and Biology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/S1074-5521(98)90616-0
State	Published - May 1998

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(98)90616-0

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title = "Stretching exercises - Flexibility in dihydrofolate reductase catalysis",

abstract = "As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.",

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AU - Miller, Grover Paul

AU - Benkovic, Stephen J.

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AB - As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

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DO - 10.1016/S1074-5521(98)90616-0

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Stretching exercises - Flexibility in dihydrofolate reductase catalysis

Abstract

All Science Journal Classification (ASJC) codes

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