Stretching exercises - Flexibility in dihydrofolate reductase catalysis

Grover Paul Miller, Stephen J. Benkovic

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

Original languageEnglish (US)
Pages (from-to)R105-R113
JournalChemistry and Biology
Issue number5
StatePublished - May 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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