TY - JOUR
T1 - Strong-field ionization of sputtered molecules for biomolecular imaging
AU - Willingham, D.
AU - Kucher, A.
AU - Winograd, N.
N1 - Funding Information:
Financial support from the National Institute of Health under Grant # EB002016-15, and the Department of Energy Grant # DE-FG02-06ER15803 are acknowledged. We also thank Robert Levis and Andreas Wucher for their many consultations.
PY - 2009/1/22
Y1 - 2009/1/22
N2 - Photoionization of molecules sputtered from molecular thin films has been achieved using high field 125 fs pulses in the mid-IR spectral range. Using several model systems, we show that it is possible to significantly reduce molecular fragmentation induced by the laser field by increasing the photoionization wavelength. By examining the photoionization spectra as a function of wavelength, it is apparent that the photoionization mechanism is changing from a non-adiabatic multi-electron excitation process to a process that involves tunnel ionization. The results of these observations are discussed in terms of their significance for bioimaging with focused ion beams and mass-spectrometry.
AB - Photoionization of molecules sputtered from molecular thin films has been achieved using high field 125 fs pulses in the mid-IR spectral range. Using several model systems, we show that it is possible to significantly reduce molecular fragmentation induced by the laser field by increasing the photoionization wavelength. By examining the photoionization spectra as a function of wavelength, it is apparent that the photoionization mechanism is changing from a non-adiabatic multi-electron excitation process to a process that involves tunnel ionization. The results of these observations are discussed in terms of their significance for bioimaging with focused ion beams and mass-spectrometry.
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U2 - 10.1016/j.cplett.2008.11.094
DO - 10.1016/j.cplett.2008.11.094
M3 - Article
C2 - 20428490
AN - SCOPUS:58149394840
SN - 0009-2614
VL - 468
SP - 264
EP - 269
JO - Chemical Physics Letters
JF - Chemical Physics Letters
IS - 4-6
ER -