@article{dfa46e575b624b94b4cfc659e4ffed84,
title = "Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure",
abstract = "The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported.",
author = "Ulrich, {Natalie C.} and Kodet, {John G.} and Mente, {Nolan R.} and Kuder, {Craig H.} and Beutler, {John A.} and Hohl, {Raymond J.} and Wiemer, {David F.}",
note = "Funding Information: We thank Dr. David G. Covell, NCI-Frederick, for helpful discussions. This project was supported at the UI by the Roy J. Carver Charitable Trust as a Research Program of Excellence, the Roland W. Holden Family Program for Experimental Cancer Therapeutics, and the NIH through R41CA126020-01 to Terpenoid Therapeutics, Inc. This research at the NCI was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research; we thank the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute, for 60-cell testing. ",
year = "2010",
month = feb,
day = "15",
doi = "10.1016/j.bmc.2009.12.063",
language = "English (US)",
volume = "18",
pages = "1676--1683",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd",
number = "4",
}