Structural basis for the inhibition mechanism of human cystathionine γ-lyase, an enzyme responsible for the production of H₂S

Keyphrases

• Inhibition Mechanism 100%
• Cystathionine Lyase 100%
• Pyridoxal 5′-phosphate 33%
• Biochemical Studies 16%
• Structural Characterization 16%
• Hydrogen Sulfide 16%
• Disease Symptoms 16%
• Pyridoxal-5′-phosphate-dependent Enzymes 16%
• Hypertension 16%
• Bound Form 16%
• Type 1 Diabetes Mellitus (T1DM) 16%
• Binding Mode 16%
• Enzyme Complex 16%
• Large Conformational Changes 16%
• Septic Shock 16%
• Novel Inhibitors 16%
• Biophysical Studies 16%
• Hemorrhagic Shock 16%
• Sulfur Metabolism 16%
• Cystathionine Synthase 16%
• Gasotransmitter 16%
• Apo Form 16%
• Structure-based Design 16%
• Open Form 16%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Lyase 100%
• Cystathionine 100%
• Synthase 20%
• Conformational Change 20%
• Crystal Structure 20%
• Hydrogen Sulfide 20%
• Sulfur Metabolism 20%