TY - JOUR
T1 - Structural modifications imparting reduced toxicity in microcystins from Microcystis spp.
AU - Stotts, Richard R.
AU - Namikoshi, Michio
AU - Haschek, Wanda M.
AU - Rinehart, Kenneth L.
AU - Carmichael, Wayne W.
AU - Dahlem, Andrew M.
AU - Beasley, Val R.
N1 - Funding Information:
Acknowledgements-This study was supported in part by a grant from the National Institute of Allergy and Infectious Diseases (AL 04769) to K.L .R . and a subcontract from the same grant to W.W.C .
PY - 1993/6
Y1 - 1993/6
N2 - R. R. Stotts, M. Namikoshi, W. M. Haschek, K. L. Rinehart, W. W. Carmichael, A. M. Dahlem and V. R. Beasley. Structural modifications imparting reduced toxicity in microcystins from Microcystis spp. Toxicon 31, 783-789, 1993.-A cyanobacterial (blue-green algal) bloom containing Microcystis aeruginosa (dominant), M. viridis, and M. wesenbergii, was collected from Homer Lake (Illinois, U.S.A.) in the summer of 1988 and microcystins were isolated. One microcystin of substantially reduced toxicity was isolated, together with ten hepatotoxic microcystins. The compound with reduced toxicity was nonlethal at 1 mg/kg (i.p. mouse) and was determined to have a (C3H7O2) mono-ester of the α-carboxyl on the Glu unit of microcystin-LR. The other nine microcystins apart from MCLR had approximate ld50s ranging from 97 μg/kg to 750 μg/kg.
AB - R. R. Stotts, M. Namikoshi, W. M. Haschek, K. L. Rinehart, W. W. Carmichael, A. M. Dahlem and V. R. Beasley. Structural modifications imparting reduced toxicity in microcystins from Microcystis spp. Toxicon 31, 783-789, 1993.-A cyanobacterial (blue-green algal) bloom containing Microcystis aeruginosa (dominant), M. viridis, and M. wesenbergii, was collected from Homer Lake (Illinois, U.S.A.) in the summer of 1988 and microcystins were isolated. One microcystin of substantially reduced toxicity was isolated, together with ten hepatotoxic microcystins. The compound with reduced toxicity was nonlethal at 1 mg/kg (i.p. mouse) and was determined to have a (C3H7O2) mono-ester of the α-carboxyl on the Glu unit of microcystin-LR. The other nine microcystins apart from MCLR had approximate ld50s ranging from 97 μg/kg to 750 μg/kg.
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U2 - 10.1016/0041-0101(93)90384-U
DO - 10.1016/0041-0101(93)90384-U
M3 - Article
C2 - 8342176
AN - SCOPUS:0027254410
SN - 0041-0101
VL - 31
SP - 783
EP - 789
JO - Toxicon
JF - Toxicon
IS - 6
ER -