Structural Requirements for Activity of Phenoxazines for Reversal of Drug Resistance in Cancer Cells

Keyphrases

• In Cancer 100%
• Cancer Cells 100%
• Verapamil 100%
• Structural Requirements 100%
• Drug Resistance Reversal 100%
• Efflux 80%
• Cytotoxicity 60%
• Bromo 40%
• P-glycoprotein (P-gp) 40%
• Compound 3 40%
• Lipophilicity 40%
• Benzene 20%
• Steady State 20%
• Propyl 20%
• Iodide 20%
• Condensation 20%
• Cell-Associated 20%
• Compound II 20%
• Butyl 20%
• 1H nuclear Magnetic Resonance (1H NMR) 20%
• Biological Activity 20%
• Pyrrolidine 20%
• Hydrophobicity 20%
• Enhancement Effect 20%
• Cancer Therapy 20%
• At a Distance 20%
• Antiproliferative Activity 20%
• Vinblastine 20%
• Structural Features 20%
• IC50 Value 20%
• Organic Solvents 20%
• Pyrolytic 20%
• Good Yield 20%
• Irm-NMR 20%
• Acetyl 20%
• Chloro 20%
• 13C NMR 20%
• Co-incubation 20%
• Partition Coefficient 20%
• Trifluoromethyl 20%
• Tetrabutylammonium Bromide 20%
• Hydroxyethyl 20%
• Morpholine 20%
• UV-IR 20%
• Mass Spectral Data 20%
• Aqueous Two-phase System 20%
• Piperazine 20%
• Chloropropane 20%
• Nucleophilic Substitution 20%
• N-alkylation 20%
• Compound 9 20%
• Secondary Amines 20%
• Carbon Chain 20%
• Piperidine 20%
• Potassium Hydroxide 20%

Chemistry

• Phenoxazine 100%
• 2-Bromophenol 20%
• Morpholine 20%
• Tertiary Amino Group 20%
• Diethylamine 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Diethanolamine 20%
• Diethylamine 20%
• Piperidine 20%