Structural Risk Minimisation based gene expression profiling analysis

Xue Wen Chen, Byron Gerlach, Dechang Chen, Zhenqiu Liu

Research output: Contribution to journalArticlepeer-review


For microarray based cancer classification, feature selection is a common method for improving classifier generalisation. Most wrapper methods use cross validation methods to evaluate feature sets. For small sample problems like microarray, however, cross validation methods may overfit the data. In this paper, we propose a Structural Risk Minimisation (SRM) based method for gene selection in cancer classification. SRM principle allows for reducing the probable bound on generalisation error and thus avoids overfitting problems. The experimental results show that the proposed method produces significantly better performance than general wrapper methods that use cross validations.

Original languageEnglish (US)
Pages (from-to)153-169
Number of pages17
JournalInternational Journal of Bioinformatics Research and Applications
Issue number2
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics
  • Clinical Biochemistry
  • Health Information Management


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