Structural transformation: Assembly of an otherwise inaccessible DNA Nanocage

Yulin Li; Cheng Tian; Zhiyu Liu; Wen Jiang; Chengde Mao

doi:10.1002/anie.201500755

Structural transformation: Assembly of an otherwise inaccessible DNA Nanocage

Yulin Li, Cheng Tian, Zhiyu Liu, Wen Jiang, Chengde Mao

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A strategy of structural transformation for the assembly of DNA nanocages that can not be assembled directly is described. In this strategy, a precursor DNA nanocage is assembled first and then is isothermally transformed into a desired, complicated nanocage. A dramatic, conformational change accompanies the transformation. This strategy has been proven to be successful by native polyacrylamide gel electrophoresis (PAGE) and cryogenic electron microscopy (cryoEM) imaging. We expect that the strategy of structural transformation will be useful for the assembly of many otherwise inaccessible DNA nanostructures and help to increase the structural complexity of DNA nanocages.

Original language	English (US)
Pages (from-to)	5990-5993
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	20
DOIs	https://doi.org/10.1002/anie.201500755
State	Published - May 11 2015

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201500755

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abstract = "A strategy of structural transformation for the assembly of DNA nanocages that can not be assembled directly is described. In this strategy, a precursor DNA nanocage is assembled first and then is isothermally transformed into a desired, complicated nanocage. A dramatic, conformational change accompanies the transformation. This strategy has been proven to be successful by native polyacrylamide gel electrophoresis (PAGE) and cryogenic electron microscopy (cryoEM) imaging. We expect that the strategy of structural transformation will be useful for the assembly of many otherwise inaccessible DNA nanostructures and help to increase the structural complexity of DNA nanocages.",

author = "Yulin Li and Cheng Tian and Zhiyu Liu and Wen Jiang and Chengde Mao",

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Structural transformation: Assembly of an otherwise inaccessible DNA Nanocage

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